Protease Inhibitors and Phosphatase Inhibitors
MilliporeSigma™ Calbiochem™ PRIMA-1
A cell-permeable quinuclidinone analog with antitumor properties.
MilliporeSigma™ Calbiochem™ Spermidine, Trihydrochloride
Polyamine that plays an important role in the regulation of cellular proliferation and differentiation.
MilliporeSigma™ Calbiochem™ Staurosporine, Streptomyces sp.
Staurosporine, CAS 62996-74-, is a cell-permeable, potent, reversible, ATP-competitive inhibitor of protein kinases (IC50 = 7, 20, 1.3, 0.7, & 8.5 nM for PKA, CAMK, MLCK, PKC, & PKG, respectively).
MilliporeSigma™ Calbiochem™ β-Secretase Inhibitor III
The β-Secretase Inhibitor III controls the biological activity of β-Secretase. This small molecule/inhibitor is primarily used for Neuroscience applications.
MilliporeSigma™ Calbiochem™ Sulindac Sulfide
A cell-permeable, active metabolite of Sulindac.
MilliporeSigma™ Calbiochem™ γ-Secretase Inhibitor XX
This γ-secretase inhibitor, CAS 209984-56-5, is a cell-permeable dibenzazepine compound that lowers both brain and plasma Aβ40 levels by ≈72% in Tg2576 mutant APP transgenic mouse model.
MilliporeSigma™ Calbiochem™ SHIP1 Inhibitor, 3AC
The SHIP1 Inhibitor, 3AC controls the biological activity of SHIP1. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.
MilliporeSigma™ Calbiochem™ Riluzole
A cell-permeable benzothiazole compound that potently inhibits glutamate release and blocks Na+ channels.
MilliporeSigma™ Calbiochem™ Syk Inhibitor IV, BAY 61-3606
The Syk Inhibitor IV, BAY 61-3606, also referenced under CAS 732938-37-8, controls the biological activity of Syk.
MilliporeSigma™ Calbiochem™ DL-threo-PDMP, Hydrochloride
PDMP closely resembles the natural sphingolipid substrate of brain glucosyltransferase and acts as a potent and competitive inhibitor of this enzyme.
MilliporeSigma™ Calbiochem™ SIRT1 Inhibitor III
The SIRT1 Inhibitor III, also referenced under CAS 49843-98-3, controls the biological activity of SIRT1. This small molecule/inhibitor is primarily used for Cell Structure applications.
MilliporeSigma™ Calbiochem™ PKCθ/δ Inhibitor
A cell-permeable pyridinecarbonitrile compound that acts as a potent, ATP-competitive (Ki = 79 nM, using PKCθ KD in coupled PK/LDH assays), and isozyme-selective PKCθ inhibitor (IC50 = 70nM) with much reduced potency against other novel PKCs (IC50
MilliporeSigma™ Calbiochem™ PAR-2 Agonist I
The PAR-2 Agonist I controls the biological activity of PAR-2. This small molecule/inhibitor is primarily used for Activators/Inducers applications.
MilliporeSigma™ Calbiochem™ Pristimerin
A cell-permeable plant dienone-phenolic triterpenoid, naturally isolated from tripterygium wilfordii.
MilliporeSigma™ Calbiochem™ PTK/PI 3-K/mTOR Inhibitor, PP121
The PTK/PI 3-K/mTOR Inhibitor, PP121, also referenced under CAS 1092788-83-4, controls the biological activity of PTK/PI 3-K/mTOR. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.